The study design will have three overlapping phases that are summarized below: 1) A one week methadone fixed induction (week 1) and flexible stabilization phase (weeks 2-9) 2) an 8-week "treatment" phase (weeks 2-9), consisting of slow titration and stabilization on study medication and 3) a four week "taper, detoxification or transfer" phase (weeks 9-12).ĭuring the first week of induction onto methadone, participants will be administered fixed increasing doses of methadone starting at 30 mg daily and increased to 60 mg daily by the end of the first week. Baseline cocaine use will be determined during the first week of treatment participation. Participants, aged 18-65 years, will receive levetiracetam 3000 mg/day while concurrently receiving treatment with methadone. This 12-week open-label clinical trial will provide treatment for 15 cocaine-dependent opioid dependent patients. Why Should I Register and Submit Results?.
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